西藥-中草藥或保健品併用實證查詢

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西藥-中草藥或保健品併用實證查詢

西藥

Type

B01AC06

Name

Aspirin

中草藥/保健品

Type

驅蟲藥

Name

大蒜 ((Garlic))

嚴重程度

1.

MICROMEDEX®

禁忌症

嚴重

中度

輕度

無交互作用

2.

Lexi-Interact™

嚴重

中度

輕度

無交互作用

3.

Natural Medicines Comprehensive Database(NMCD)

嚴重

中度

輕度

無交互作用

NMCD證據等級

A

B

C

D

機轉

藥物動力學

藥物藥效學

藥物動力學 + 藥物藥效學

未知

可能機轉

大蒜會降低thromboxane B2 而抑制血小板凝集作用

結果

可能會增加出血的危險^1-14

臨床處置

正常飲食中食用的大蒜並不會造成問題，但如果有大量攝取時 (如服用含大蒜成分的保健食品) 就應特別留意。如果可以應盡量避免併用，若須併用則建議密切監測凝血時間，以及是否有出現出血的症狀。

參考資料

1.

1. Stargrove MB, Treasure J, McKee DL. Herb, nutrient, and drug interactions :clinical implications and therapeutic strategies St. Louis, Mo.: Mosby Elsevier; 2008.

2.

2. Norred CL, Brinker F. Potential coagulation effects of preoperative complementary and alternative medicines. Altern Ther Health Med. Nov-Dec 2001;7(6):58-67.

3.

3. Kuhn MA. Herbal remedies: drug-herb interactions. Crit Care Nurse. Apr 2002;22(2):22-28, 30, 32; quiz 34-25.

4.

4. Valli G, Giardina EG. Benefits, adverse effects and drug interactions of herbal therapies with cardiovascular effects. J Am Coll Cardiol. Apr 3 2002;39(7):1083-1095.

5.

5. Brazier NC, Levine MA. Drug-herb interaction among commonly used conventional medicines: a compendium for health care professionals. Am J Ther. May-Jun 2003;10(3):163-169.

6.

6. Pal D, Mitra AK. MDR- and CYP3A4-mediated drug-herbal interactions. Life Sci. Mar 27 2006;78(18):2131-2145.

7.

7. McIntyre M. A review of the benefits, adverse events, drug interactions, and safety of St. John's Wort (Hypericum perforatum): The implications with regard to the regulation of herbal medicines. Journal of Alternative and Complementary. 2000;6(2):115-124.

8.

8. Lis-Balchin M. Serious adverse effects between herbal remedies and conventional drugs taken simultaneously. Journal of The Royal Society for the Promotion of Health. 2002;122(4):210.

9.

9. Ly J, Percy L, Dhanani S. Use of dietary supplements and their interactions with prescription drugs in the elderly. American Journal of Health-System Pharmacy. 2002;59(18):1759-1762.

10.

10. Davidson P, Hancock K, Leung D, et al. Traditional Chinese Medicine and heart disease: What does Western medicine and nursing science know about it? European Journal of Cardiovascular Nursing. 2003;2(3):171-181.

11.

11. Taylor DMD, Walsham N, Taylor SE, Wong L. Potential interactions between prescription drugs and complementary and alternative medicines among patients in the emergency department. Pharmacotherapy. 2006;26(5 I):634-640.

12.

12. Singh SR, Levine MAH. Potential interactions between pharmaceuticals and natural health products in Canada. Journal of Clinical Pharmacology. 2007;47(2):249-258.

13.

13. 毛曉琴, 謝海棠, 周宏灝. 多藥耐藥蛋白和cyp3a4介導的中草藥-西藥相互作用. Ylzl. 2007(07).

14.

14. 林聖興. 中西藥交互作用資訊網站之建構: 中西醫結合研究所, 中國醫藥大學; 2006.